The conference on Czech-Italian collaboration in space-based high-energy astronomy will spotlight the latest research breakthroughs, including the measurement of X-ray polarization around accreting black holes with the IXPE mission, and will look ahead to future international missions such as ESA’s upcoming NewAthena mission, the proposed Large Area Detector, and the ambitious Czech-led project Quvik. The event aims to deepen scientific cooperation between Czech and Italian research communities, both of which share a rich tradition and exceptional track record in this field. A highlight of the program will be the awarding of the prestigious Ernst Mach Medal to Professor Enrico Costa for his pioneering contributions to X-ray polarimetry and his long-standing collaboration with the Prague Relativistic Astrophysics group in the study of accreting black holes. The conference is organized by the Astronomical Institute of the Czech Academy of Sciences, in cooperation with the Italian Embassy and with the support of the Czech Academy of Sciences’ Space for Humankind initiative.